Some studies suggest a potential link between Methylenetetrahydrofolate reductase (MTHFR) gene variations and increased Attention-Deficit/Hyperactivity Disorder (ADHD) risk. MTHFR, vital for folate metabolism and neurotransmitter synthesis, may impact brain function with altered folate metabolism. Clear connection requires more research, given individual variations. Clinical implications of MTHFR mutations involve assessing risks like cardiovascular disease, neural tube defects, and pregnancy complications. Testing aids personalized healthcare, promoting early interventions for improved health outcomes. Consultation with healthcare professionals is crucial for accurate assessment and guidance.