ABO and Rh typing are crucial in blood transfusions and pregnancy. ABO determines blood group (A, B, AB, O), while Rh identifies Rh-positive or Rh-negative status. Clinical implications include safe blood transfusions by matching donor and recipient blood types, preventing transfusion reactions. In pregnancy, Rh incompatibility can lead to hemolytic disease, causing jaundice and anemia in the newborn. Timely ABO and Rh typing are essential for personalized medical interventions and ensuring positive health outcomes.