The QuantiFERON Tuberculosis Screening test is vital for individuals exposed to TB risks, such as healthcare workers, close contacts of active TB cases, and those in TB-endemic regions. It detects TB by measuring interferon-gamma response to TB antigens, offering more accuracy than skin tests and uninfluenced by prior TB vaccines. This diagnostic tool detects latent TB and guides TB management in high-risk groups. Precise test interpretation and personalized guidance are crucial, underscoring the importance of consulting with a healthcare provider.