Fatigue, weight changes, and mood or temperature disturbances may
arise from low Thyroxine Binding Globulin (TBG) levels, commonly associated
with malnutrition or liver disease. Conversely, elevated TBG levels during
pregnancy or due to genetic factors can lead to changes in weight, energy
levels, and mood. While TBG levels themselves don’t directly cause symptoms,
their variations significantly impact thyroid function. Monitoring TBG levels
is vital in diagnosing thyroid disorders, and treatment focuses on addressing
underlying causes and managing thyroid hormones to alleviate associated
symptoms.