Fatigue, weakness, weight loss, low blood pressure, and difficulty handling stress may result from low levels of Adrenocorticotropic hormone (ACTH), leading to adrenal insufficiency. Conversely, elevated ACTH levels, often seen in conditions like Cushing’s disease, can cause symptoms such as weight gain, high blood pressure, muscle weakness, and changes in skin appearance, including thinning and bruising. Monitoring ACTH levels is crucial for diagnosing and managing these conditions. Treatment involves addressing the underlying cause