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Protime and PTT

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Protime and PTT – Grand Prairie, TX

The prothrombin time (PT) helps determine the integrity of the extrinsic and common pathways of coagulation by measuring the clotting time, from the activation of factor VII through the formation of fibrin clot. The activated partial thromboplastin time (aPTT or PTT) measures clotting time from the activation of factor XII, through the formation of fibrin clot. This measures the integrity of the intrinsic and common pathways of coagulation.

PTT prolongations are caused by either factor deficiencies (especially of factors VIII, IX, XI, and/or XII), or inhibitors (most commonly, lupus anticoagulants, or medications such as heparin or argatroban).

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